|
KMID : 0363120180310010039
|
|
Korean Journal of Pain
2018 Volume.31 No. 1 p.39 ~ p.42
|
|
|
Double blind randomized control trial to evaluate the efficacy of ketoprofen patch to attenuate pain during venous cannulation
|
|
Kumar Sanjay
Sanjeev Omprakash
Agarwal Anil
Shamshery Chetna
Gupta Rakhi
|
|
|
Abstract
|
|
|
Background: Venipuncture pain is an uncomfortable suffering to the patient. It creates anxiety, fear and dissatisfaction. The ketoprofen transdermal patch is a proven treatment for musculoskeletal and arthritic pain. We planned this study to evaluate the efficacy of the ketoprofen patch to reduce venipuncture pain.
Methods: Two hundred adult patients, aged 18?60 years, of either sex, ASA grade I or II, were enrolled. Presuming that therapy would decrease venipuncture pain by 30%, a power calculation with α = 0.05 and β = 0.80 required enrollment of at least 24 patients into each group. However, 100 patients in each group were recruited. Group I (Control) received a placebo patch; Group II (Ketoprofen) received a 20 mg ketoprofen patch. A selected vein on the dorsum of the patient’s non-dominant hand was cannulated with 18 g intravenous cannula 1 h after the application of the respective patch. Assessment of pain was done by a 10 cm visual analogue scale (VAS) of 0?10, where 0 depicts “no pain” and 10 is “the worst imaginable pain”. The venipuncture site was assessed for the presence of skin erythema, swelling and rashes at 12 h, 24 h and at the time of decannulation.
Results: Incidence of pain was 100% (94/94) in the control group as compared to 93% (85/91) in the ketoprofen group. The severity of the venipuncture pain was 6 (2) and 2 (2) for control and ketoprofen groups respectively (P ＜ 0.05).
Conclusions: Application of a ketoprofen patch at the proposed site of venipuncture one hour before the attempt is effective and safe for attenuating venipuncture pain.
|
|
|
KEYWORD
|
|
|
Erythema, Ketoprofen, Nonsteroidal anti-inflammatory drugs, Pain, Venipuncture, Visual analog scale
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|
|